In support of these results, several studies have successfully induced apoptosis in cancer cells by using a cell-permeable stapled BH3 peptides.16, 47 Furthermore, previous studies have shown that the Bim helix colocalises well – but not perfectly – with mitochondria,47 and that, following transfection of the Bim BH3 peptide into HeLa cells, cytochrome c release was observed in most cells.11 This evidence concerns the gene BCL2L11 and cancer.