PKM and central nervous system cancer: Recently, PKM2 has been shown to interact with several nuclear proteins such as HIF-135 and Histone H3.18 Hypoxia is commonly observed in gliomas and it has been suggested that it was regulating self-renewal and multipotency of CSC as well as glucose metabolism.22 We thus examined the effect of DCA on the HIF-1: PKM2 interaction under hypoxic conditions (that is, 5% O2).