The oncogenic activity of GLI2 interacts with a number of biological processes, leading to the inhibition of apoptosis, resistance to growth arrest and suppression of epithelial differentiation; as such, Gli2ΔN alone is sufficient for the generation of BCC tumors.17, 18, 19 In this study we show for the first time, to our knowledge, that activation of GLI2ΔN can induce GIN, a widespread feature of human cancer. This evidence concerns the gene GLI2 and skin basal cell carcinoma.