GLI2 is frequently overexpressed in human cancers associated with aneuploidy and CIN, including human BCCs, prostate, breast, hepatocellular, colon and oral squamous cancers, osteosarcomas and melanomas.5, 10, 12, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 38, 41, 42, 43, 44 However, its role in aneuploidy and CIN has not previously been reported. Here, GLI2 is linked to melanoma.