Putting together the observations that ectopic wild-type CITED1 expression in the WiT49 cell line foremost induces concomitant LGR5 upregulation and CDH6 downregulation, we speculate that this combined effect confers stem-like properties to the metanephric blastema and that WTs hijack this trait to maintain its putative cancer stem cell. This evidence concerns the gene LGR5 and cancer.