Here (Fig. 6B) we report that radiation induces ER stress in human carcinoma cells, triggering a survival response, which encompasses the PERK branch of the UPR, resulting in increased expression of multiple APM components and other immune-relevant proteins, consistent with observations with the ER-stress inducer thapsigargin (Figs. 3–4, Supplemental Table 1). This evidence concerns the gene EIF2AK3 and carcinoma.