HMGB1 and lung carcinoma: In contrast, 10 Gy significantly reduced growth in all cell lines (P ≤ 0.005) without significantly reducing viability (Fig. 1A), yet also induced significant ATP release in lung cancer cells (Fig. 1B; P = 0.0002) and HMGB1 secretion in lung (P = 0.0003) and prostate (P = 0.0007) cancer cells (Fig. 1C).