To delineate the role of IFN in pancreatitis we used a clinically relevant model involving injections of caerulein peptide that mimics the effects of cholecystokinin and induces key pathogenetic elements of acute pancreatitis including pancreatic duct obstruction and premature activation of trypsin (Pandol, 2006; Reichert et al, 2013). The gene discussed is CCK; the disease is acute pancreatitis.