In order to elucidate the potential protective role of GSTM2 in the pathogenesis of immune-mediated nephritis, and also to explore possible therapeutic approaches using this molecule for lupus nephritis, we used genetically modified mesenchymal stem cells (MSCs) as carriers to deliver GSTM2 into the kidney of anti-GBM antibody-challenged mice, and evaluated the effects of these MSCs on anti-GBM-GN. The gene discussed is GSTM2; the disease is lupus nephritis.