Glutathione S-transferase Mu 2, a protein involved in detoxification of ROS, was significantly increased in anti-GBM-resistant strains (B6 and BALB/c), but decreased in anti-GBM-sensitive strains (129/svj, DBA1, and NZW), suggesting that GSTM2 may play a protective role in anti-GBM induced nephritis. The gene discussed is GSTM2; the disease is glioblastoma.