Specifically, in stage 1 (non-obese cohort) ANKS1B had a tissue type-by-smoking status interaction p-value of 0.0008; the fold change of expression between smokers and non-smokers was 1.08 (p = 0.02) in normal tissues and 0.92 (p = 0.01) in tumor tissues (Table 2). Here, ANKS1B is linked to neoplasm.