The mechanism for this low expression in HemECs was shown to be the sequestration of β1-inergrin in a multiprotein complex composed of tumor endothelial marker-8 (TEM8) and VEGFR-2, which inhibits nuclear factor in activated T cells (NFAT)-mediated VEGFR-1 transcription[40]. This evidence concerns the gene FLT1 and neoplasm.