We have shown that zeaxanthin administration in diabetic rats prevents increase in retinal oxidative stress and proinflammatory cytokines, VEGF, ICAM-1 [26], and antioxidants containing vitamin C, vitamin E, β-carotene, N-acetyl cysteine and other micronutrients inhibit the development of diabetic retinopathy [4,24]. Here, VEGFA is linked to diabetic retinopathy.