The Runt-related transcription factor, Runx2, is a key regulator of normal bone development, homeostasis and remodeling [4]; however, Runx2 is also aberrantly expressed in several cancer types, including breast [5,6], prostate [7], lung [8], ovarian [9] and osteosarcoma [10,11]. Here, RUNX2 is linked to osteosarcoma.