HNF1B and ovarian carcinoma: Additionally, Genome-wide association studies (GWAS) in the context of ovarian cancer have identified 11 common risk alleles [7,19-24], and six of these are located in homeobox gene clusters (HOXA, HOXB, and HOXD), homeobox-related genes (HNF1B), or genes expressed in early progenitor cells (BNC2, TERT) [20,25,26]; many developmental genes such as these are silenced by DNAm in differentiated cells and become aberrantly hypomethylated during tumorigenesis [26].