HMGB1 and HMGB2 are the main members of the HMGB protein family and their overexpression has been observed in numerous human malignancies, including hepatocellular [59], skin squamous cell [60], prostate [61], gastrointestinal [62,63] breast [64,65], and bladder carcinomas [66]. This evidence concerns the gene HMGB1 and urinary bladder carcinoma.