Iorio and colleagues were the first to report significant deregulation in miRNA expression profiles in breast cancer when compared to normal breast tissue, where they showed that the expression of several miRNAs was associated with breast cancer subtypes and clinico-pathological features including hormone receptor status, clinical stage and proliferation index [6], suggesting that miRNA expression in breast cancer may have diagnostic and prognostic value. The gene discussed is NR4A1; the disease is breast cancer.