LRP5 is one of the most intensively studied regulators of bone remodeling, largely because Lrp5 loss-of-function mutations cause the autosomal recessive human disorder osteoporosis-pseudoglioma syndrome (OPPG)[12], whereas activating mutations in Lrp5 cause high bone mass syndrome[13]. This evidence concerns the gene LRP5 and Osteoporosis - pseudoglioma.