TP53 and lip and oral cavity carcinoma: Because a high concentration of rAd-p53 can be delivered to an oral tumor through intra-arterial infusion with minimal systemic toxicity, the aims of this randomized, placebo-controlled, double-blind, phase III clinical trial were to compare the efficacy and safety outcomes of intra-arterial infusion of combined rAd-p53 and chemotherapeutic drugs with those of the single treatments individually for treatment of oral carcinoma.