Detailed histo-pathological examination of tubal epithelia (FTE) in the genetically high-risk population undergoing risk-reducing surgery has led to the discovery of putative cancer precursor lesions in the fallopian tube, some of which, i.e., the p53 signature – described as a string of 10–12 histologically normal secretory (non-ciliated) cells expressing the TP53 protein with a low proliferation rate (Ki67) (50), are found with a similar frequency in BRCA mutation carriers and non-carriers. This evidence concerns the gene TP53 and cancer.