It took a further 8 years before the cloning of human and Xenopus KCNQ1 (then termed KvLQT1) was reported (Barhanin et al., 1996; Sanguinetti et al., 1996), KCNQ1 was linked to LQTS (Wang et al., 1996), and the KCNE1 functionality and IKs molecular correlate conundrums solved. This evidence concerns the gene KCNQ1 and familial long QT syndrome.