KCNE2 and atrial fibrillation: Some atrial fibrillation (AF)-associated KCNQ1 and KCNE2 human gene variants augment KCNQ1-KCNE2 currents (which are typically much smaller in terms of outward current even than KCNQ1 alone) and would therefore be predicted to shorten the atrial action potential, thought to predispose to AF (Yang et al., 2004) (Table S1).