In addition, features of greater plaque stability included augmented collagen/lipid ratio, reduced macrophages content, and less presence of lateral xanthomas, buried caps, medial erosion, intraplaque hemorrhage, and calcium content have been observed in TWEAK/ApoE-double knockout mice or in anti-TWEAK mAb treated ApoE-deficient mice (53). This evidence concerns the gene APOE and xanthoma.