IGHE and infection: In fact both diseases share many clinical symptoms [recurrent infections by certain types of viruses, and high IgE levels] (127, 128, 132, 152–154, 157), as well as phenotypes observed in NK cells [defective cytotoxic activity, integrin-mediated adhesion, F-actin accumulation, and polarization of lytic granules (101, 139, 140, 155, 156)].