NR3C2 and treatment resistant depression: Our group recently published (60) a study with treatment-resistant depression (TRD) patients showing that TRD had higher cortisol compared with controls after (a) the effect of combined GR/MR stimulation with prednisolone; (b) the effect of prednisolone with the MR antagonist spironolactone; and (c) the effect of spironolactone alone.