However, due to low sensitivity of the DST (20–50%) to distinguish between patients with major depression and patients with other psychiatric disorders or healthy subjects (39, 44), Holsboer et al. have developed a more sensitive neuroendocrine test (45, 46) that combines the DST and the corticotropin-releasing hormone (CRH) stimulation test, and it is called the dexamethasone/corticotrophin-releasing hormone (Dex/CRH) challenge test. This evidence concerns the gene CRH and psychiatric disorder.