Concerning the evaluation of impact of ELS in HPA axis response to challenges with GR and MR agonist in depression, our findings indicate that patients with ELS show suppression of salivary cortisol levels after fludrocortisone (MR agonist) and dexamethasone (GR agonist), indicating that patients with ELS are equally sensitive to both GR and MR. This evidence concerns the gene NR3C1 and major depressive disorder.