Systemic administration of PEGylated human recombinant PH20 hyaluronidase (PEGPH20) [an enzymatic agent that targets a critical component of the desmoplastic stroma in pancreatic cancer known as hyaluronic acid (HA)] (Provenzano et al., 2012) in a murine pancreatic cancer model, produced a marked decrease in tumor stroma which correlated to a rapid and signi?cant decrease in interstitial tumor pressure and increased tumor blood vessel lumen diameter. Here, SPAM1 is linked to familial pancreatic carcinoma.