PDX1 and pancreatic neoplasm: Indeed, studies have demonstrated several members of the MUC protein family to be overexpressed and/or aberrantly glycosylated during the progression of early PanIN lesions to pancreatic tumors in a mouse transgenic model (KrasG12D;Pdx1-Cre), which mimics the human setting for the initiation and progression of pancreatic cancer (Rachagani et al., 2012; Remmers et al., 2013).