SLC9A1 and cardiac hypertrophy: More importantly, in a model of cardiac hypertrophy due to NHE-1 overexpression, the NHE-1 is distributed all around the sarcolemma (Nakamura et al., 2008), further suggesting that the pathological remodeling of these transporters could be, at least in part, responsible for the [Na+]i and [Ca2+]i overload-mediated cardiac hypertrophy (Garciarena et al., 2013b) (Figure 2).