In this regard, it has been described that Ang II and aldosterone directly stimulate the cardiac NHE-1, which is involved in the positive inotropic response (Perez et al., 2003; Caldiz et al., 2011) and cardiac hypertrophy (Cingolani et al., 2008, 2013) produced by these hormones. This evidence concerns the gene SLC9A1 and cardiac hypertrophy.