KRAS and familial pancreatic carcinoma: It is interesting to note, however, that efforts to use mutant Kras (detected in the pancreatic juice) as biomarker of pancreatic cancer have not been successful, as Kras mutations are common in an age-dependent manner even in people who are devoid of pancreatic malignancy (Yakubovskaya et al., 1995; Lu et al., 2002; Yan et al., 2005; Parsons and Meng, 2009).