In our study Nogo-A KD rats did not show deficits in reward sensitivity; although anhedonia – which is defined as the decreased capacity to experience pleasure – has long been considered a symptom in SCZ, more recent research supports the idea that hedonic processing itself is indeed normal in patients but that cognitive deficits instead lead to negatively biased self-report about hedonic experience (Strauss and Gold, 2012). This evidence concerns the gene RTN4 and Cognitive impairment.