CCK and Anxiety: SST microinfusions in the amygdala produce anxiolytic- and antidepressant-like effects (Yeung and Treit, 2012), likely through modulation of GABAA receptor signaling (Engin et al., 2008), whereas administration of CCK elicits anxiety-like behavioral responses (Mathew et al., 2008; Sherrin et al., 2009).