However, although KCC2 downregulation has been demonstrated to be a key factor in the appearance of hyperreflexia and spasticity after such injuries, we did not found changes in the KCC2 dephosphorylation that could explain the appearance of spastic behavior at the late stage (16 weeks of age) of the ALS murine model. Here, SLC12A5 is linked to amyotrophic lateral sclerosis.