Along these lines, many groups have reported association of the NRG1 – ERBB4 risk variants with neurocognitive (Stefanis et al., 2007), electrophysiological (Roussos et al., 2011) and neuroimaging schizophrenia-related outcome variables, including altered fronto-temporal brain function (Hall et al., 2006) and white matter density and integrity (McIntosh et al., 2008; Konrad et al., 2009). This evidence concerns the gene NRG1 and schizophrenia.