Furthermore, considering that it has been recently demonstrated the correlation between Pin1 activity reduction and the essential hypertension (Wang et al., 2013a,b), the isomerase partial loss of function might be detrimental in multiple interrelated disease; hence the role of Pin1 in HIF-1α regulation might contribute to the morbidity of hypertension, becoming in turn a risk factor for stroke and AD. The gene discussed is HIF1A; the disease is Alzheimer disease.