TNFRSF11A and bone neoplasm: LNRANKL cells with RANK knockdown (Fig. 6A) formed very small tumors in mice tibias, undetectable by NIR dye-based fluorescence imaging (Yang et al. 2010) but detectable by X-ray (Fig. 6B); moreover, the tumors were less osteolytic and much less bone resorptive compared with bone tumors derived from control shRNA-transduced LNRANKL cells (Fig. 6C).