Previous reports identified a potential role for VCAM1–integrin interaction (Lu et al. 2011), hematopoietic stem cells (Park et al. 2011), immunoregulatory T-cells (Tan et al. 2011), cancer-associated fibroblasts or macrophages (Paland et al. 2009, Qian et al. 2011), and soluble protein factors like HGF, bone morphogenic proteins, insulin-like growth factors, the bone TF RUNX2 (Akech et al. 2010, Gherardi et al. 2012, Hiraga et al. 2012), and microRNAs (Cai et al. 2013) in cancer metastasis. The gene discussed is HGF; the disease is cancer.