RUNX2 and cancer: Previous reports identified a potential role for VCAM1–integrin interaction (Lu et al. 2011), hematopoietic stem cells (Park et al. 2011), immunoregulatory T-cells (Tan et al. 2011), cancer-associated fibroblasts or macrophages (Paland et al. 2009, Qian et al. 2011), and soluble protein factors like HGF, bone morphogenic proteins, insulin-like growth factors, the bone TF RUNX2 (Akech et al. 2010, Gherardi et al. 2012, Hiraga et al. 2012), and microRNAs (Cai et al. 2013) in cancer metastasis.