Examples of predictive markers are epidermal growth factor receptor (EGFR) and k-RAS mutations in non-small cell lung cancer that guide the use of EGFR-specific tyrosine kinase inhibitors [28] or HER2 overexpression or amplification that indicates the treatment with anti-HER2 antibodies [29] or adjuvant anthracyclines [30]. This evidence concerns the gene ERBB2 and non-small cell lung carcinoma.