Although there has been conflicting evidence on the role of CCR5 in ECM with CCR5−/− mice reported to be either 80% resistant to P. berghei ANKA-mediated CM (Belnoue et al.2003b) or to display only a delayed onset of cerebral disease symptoms (Nitcheu et al.2003), mixed-Plasmodium species infection experiments support a role for this trafficking pathway in CM. Here, CCR5 is linked to infection.