Several studies confirmed that in the T2DM the number of type 1 muscle fibers and density of GLUT4 of slow fibers, number of capillaries around muscle fiber and oxidative capacity of muscle are decreased and the number of type 2B muscle fibers and glycolic capacity of muscle are increased [13,14,17,30,42,43]. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.