Due to the pleiotropy of vaccine, the possible mechanism is that localized expression of GM-CSF by tumor cell vaccine co-expression GM-CSF and IL-18 might specifically recruit dendritic cells (DCs) or macrophages and enhance whole tumor-antigen presentation, IL-18 secreted by vaccine could further promote the proliferation and cytotoxicity of T or NK cells which received tumor antigens presented by activated host antigen presenting cells. This evidence concerns the gene IL18 and neoplasm.