PTEN and metastatic neoplasm: In a very recent study conducted on 56 patients affected by a metastatic disease, PTEN protein expression was analyzed by an optimized PTEN IHC assay recently developed and it was found that the median OS of patients whose tumors did not express PTEN was 9 months, compared to 49 months for patients with a normal expression of PTEN [HR = 6.25, 95% confidence intervals (CI), p = 0.0023].