On the contrary with respect to the results obtained by the studies reported above, Colakoglu and colleagues, by investigating 76 CRC patients, found no correlation between PTEN immunohistochemical status and patient survival, tumor grade, TNM stage, lymphatic invasion, and liver metastasis (21), although they found a significant association between PTEN loss and local recurrence. Here, PTEN is linked to colorectal carcinoma.