As expected, the level of CD80 RNA in HSV-CD80-infected DCs was significantly higher than in parental-infected DCs at 2, 4 and 8 hr PI (Fig. 4C; p<0.001), indicating that the presence of two copies of CD80 in HSV-CD80 leads to increased expression of CD80 during the early period of infection. Here, CD80 is linked to infection.