SOAT1 and amyotrophic lateral sclerosis: In addition, the most striking differences in LL-KEGG pathway analysis were the enrichment for specific intracellular signalling pathways, such as MAPK, and PI3K, cascades commonly involved in signal transduction from the cell membrane and involved in cell survival in ALS [23], [24] as well as the JAK/STAT pathway, a regulator of neuronal apoptosis [25].