FUS and amyotrophic lateral sclerosis: Taking into account the relatively small number of ALS patients and controls in this study, drawing conclusions regarding pathway analysis should be cautious, however examples of pathways involved in ALS include: defects in RNA processing [2], and thus changes in expression of ribosome-associated genes during disease may arise from the aggregation of proteins such as TDP-43 and FUS, and down-stream effects e.g. on stress granule formation arising from dissociating ribosomes [22].