Therefore, the results obtained with TRP2-shRNA_#1 and #3 suggest that TRP2 does not play a role in the regulation of p53 while induction of p53 reporter gene activity upon infection with the most effective TRP2-shRNA_#2 in some of the cells would be consistent with an inhibitory function of TRP2 in the p53 pathway. Here, TP53 is linked to infection.