Antigen presentation by major histocompatibility complex (MHC) class II molecules (MHC-II), known as HLA-II (HLA-DR, -DP, -DQ) in humans and co-chaperones HLA-DM and the invariant chain (Ii) are important for the development of adaptive immune responses including anti-tumor immunity [1]–[4]. Here, HLA-DMA is linked to neoplasm.