CD4+ T cells activated either in the presence of IL-6 and TGF-β, or IL-6, IL-1 and IL-23 both produce IL-17, but those skewed with TGF-β appear to be less inflammatory and fail to transfer susceptibility to experimental autoimmune encephalomyelitis (EAE) [15], [16]. The gene discussed is CD4; the disease is experimental autoimmune encephalomyelitis.