In a previous study, our center has proposed the Hangzhou criteria [11], which are as follows: patients without macrovascular invasion who have one of the two following items: (a) total tumor diameter less than or equal to 8 cm; (b) total tumor diameter more than 8 cm, simultaneously with histopathologic grade I or II and preoperative alpha fetoprotein (AFP) level less than or equal to 400 ng/mL. This evidence concerns the gene AFP and neoplasm.