Wen et al. found that triple negative breast cancers present high levels of ID4 protein respect to the other breast cancers and propose that overexpression of ID4 could functionally inactivate BRCA1 in this tumor type which presents characteristics similar to BRCA1-mutant tumors and downregulation of BRCA1 [45]. The gene discussed is BRCA1; the disease is triple-negative breast carcinoma.