Fig. 6A showed that RUNX3 protein was over-expressed after stably infected with LV5-RUNX3. Tumors in mice stably infected with LV5-RUNX3 had sustained a significant growth arrest compared with the controls (P<0.05). A representative photograph showing tumor growth in control and RUNX3 expressed mice (Fig. 6B). Here, RUNX3 is linked to neoplasm.