When CCSP/TGFα mice are administered Dox, the mice develop progressive pulmonary fibrosis characterized by specific phenotypes observed in human fibrotic disease, including epithelial and mesenchymal proliferation with myofibroblast differentiation, progressive migration of fibrotic lesions from the pleura into the interstitium, extracellular matrix deposition, severe restrictive changes in lung mechanics, and secondary pulmonary hypertension [21], [26]. This evidence concerns the gene TGFA and pulmonary fibrosis.