By overlaying the rrp8  =  (bbabab) case-control differentiating pattern (dashed line cycles) over these actual case-specific genotype profiles it is shown that the rrp8 pattern does not share any relationship with these 5 melanoma-characteristic CTLA-4 SNP co-occurrence patterns, indicating the possibility of disease risk identification not by presence, but actually absence of specific genotype profile. The gene discussed is RRP8; the disease is melanoma.