We anticipated that some of the genetic risk SNP for CAD would act through established CAD risk factors, including BMI, waist/hip ratio, LDL-C, HDL-C, total cholesterol, triglycerides, ApoA1, ApoB, ApoB/A1 ratio, blood pressure, heart rate, hypertension and type 2 diabetes. The gene discussed is APOB; the disease is type 2 diabetes mellitus.