In other organ systems, loss of PAR1 signalling has been shown to be protective in a mouse model of crescentic glomerulonephritis in parallel with a decrease in renal macrophage number, and PAR-1 deficiency causes amelioration of bleomycin-induced lung injury in association with a reduction in macrophage recruitment to alveolar airspaces [13], [29]. Here, F2R is linked to crescentic glomerulonephritis.