This was also consistent with a local study conducted on diabetic patients with comorbid hypertension [32].Apart from that, antiplatelet agents and anticoagulants were found in this study to cause bleeding disorders, whereas antihypertensive agents including ACE-inhibitors and diuretics were associated with persistent dry cough, hyponatremia, and gynaecomastia, respectively [37], [38]. This evidence concerns the gene ACE and Gynecomastia.