Although Ganesh et al. reported that Akkermansia muciniphila exacerbates Salmonella typhimurium induced gut inflammation in animal model [69], recently two studies have reported that Akkermansia muciniphila ameliorates high fat diet induced obesity, metabolic endotoxemia and type 2 diabetes via modulation of Foxp3 regulatory T cells [10], [70]. The gene discussed is FOXP3; the disease is obesity due to melanocortin 4 receptor deficiency.