IGF1R and intrahepatic cholangiocarcinoma: Lőrincz et al first reported in mouse gut that the phenotype of early progenitors of ICC was c-KitlowCD44+CD34+Insr+Igf1r+, and the phenotype of committed progenitors of ICC was c-Kit+CD44+CD34+Insr+Igf1r+[32].