The 3D network structures of c-Kit positive cells were damaged in this segment (Fig. 2E, F). In the proximal segment, c-Kit positive mature ICC (Fig. 1E) and some of their 3D network structures of c-Kit were observed (Fig. 2C, D). In its AP level the c-Kit+/CD34+/Igf1r+ cells were found occasionally (Fig. 1E–H). Here, IGF1R is linked to intrahepatic cholangiocarcinoma.