Over expression of Insulin-like growth factor binding proteins-2,3 was reported in glioma [39], [40], [41] and it is known to be a modulator of the action of insulin-like growth factors (IGFs), whereas IGF-independent effects of IGFBP-2 on cellular proliferation, apoptosis, and mobility have also been revealed [41]. Here, IGFBP2 is linked to central nervous system cancer.